Biological Sciences, Division of

[ undergraduate program | graduate program | faculty ]

All courses, faculty listings, and curricular and degree requirements described herein are subject to change or deletion without notice. Updates may be found on the Academic Senate website: http://senate.ucsd.edu/catalog-copy/approved-updates/.

Courses

For course descriptions not found in the UC San Diego General Catalog, 2014–15, please contact the department for more information.

Note: The division will endeavor to offer as many of the courses listed below as possible; however, not all courses are offered every quarter, every year, or on a regular basis. Courses required for the major may be scheduled on the same day and/or same time. Students are strongly advised to check the Schedule of Classes or http://biology.ucsd.edu for the most up-to-date information. This is of particular importance in planning schedules to meet minimum graduation requirements in a timely fashion.

Prerequisites are strictly enforced in all courses offered by the Division of Biological Sciences. Please visit http://biology.ucsd.edu for the most up-to-date information.

Students who do not attend the first thirty minutes of the first scheduled meeting (be it lab or lecture) will be considered not enrolled in the course and may be administratively dropped. Prior written notification to the instructor regarding an anticipated absence may ensure a space.

IF A STUDENT DROPS A LAB COURSE AFTER THE END OF THE SECOND SCHEDULED LAB SESSION, THE DIVISION WILL REPORT A W FOR THE COURSE.

Lower Division

BILD 1. The Cell (4)

An introduction to cellular structure and function, to biological molecules, bioenergetics, to the genetics of both prokaryotic and eukaryotic organisms, and to the elements of molecular biology. Prerequisites: Chem 6A; Chem 6B may be taken concurrently.

BILD 2. Multicellular Life (4)

An introduction to the development and the physiological processes of plants and animals. Included are treatments of reproduction, nutrition, respiration, transport systems, regulation of the internal environment, the nervous system, and behavior. Prerequisites: BILD 1.

BILD 3. Organismic and Evolutionary Biology (4)

The first principles of evolutionary theory, classification, ecology, and behavior; a phylogenetic synopsis of the major groups of organisms from viruses to primates. Prerequisites: none. (Note: EBE majors should complete this course during their first year at UC San Diego.)

BILD 4. Introductory Biology Lab (2)

Students gain hands-on experience and learn the theoretical basis of lab techniques common to a variety of biological disciplines such as biochemistry, molecular biology, cell biology, and bioinformatics. Students will work in groups, learning how to collect, analyze, and present data while using the scientific method to conduct inquiry-based laboratory experiments. Program or material fee may apply. Prerequisites: BILD 1.

BILD 7. The Beginning of Life (4)

An introduction to the basic principles of plant and animal development, emphasizing the similar strategies by which diverse organisms develop. Practical applications of developmental principles as well as ethical considerations arising from these technologies will be discussed. Prerequisites: none.

BILD 10. Fundamental Concepts of Modern Biology (4)

An introduction to the biochemistry and genetics of cells and organisms; illustrations are drawn from microbiology and human biology. This course is designed for nonbiology students and does not satisfy a lower-division requirement for any biology major. Open to nonbiology majors only. Exclude the following major codes: BI28, BI29, BI30, BI31, BI32, BI33, BI34, BI35, BI36. Note: Students may not receive credit for BILD 10 after receiving credit for BILD 1.

BILD 12. Neurobiology and Behavior (4)

Introduction to the organization and functions of the nervous system; topics include molecular, cellular, developmental, systems, and behavioral neurobiology. This course is designed for nonbiology students and does not satisfy a lower-division requirement for any biology major. Open to nonbiology majors only. Exclude the following major codes: BI28, BI29, BI30, BI31, BI32, BI33, BI34, BI35, BI36.

BILD 18. Human Impact on the Environment (4)

Course will focus on issues such as global warming, species extinction, and human impact on the oceans and forests. History and scientific projections will be examined in relation to these events. Possible solutions to these worldwide processes and a critical assessment of their causes and consequences will be covered. Prerequisites: none.

BILD 20. Human Genetics in Modern Society (4)

Fundamentals of human genetics and introduction to modern genetic technology such as gene cloning and DNA finger printing. Applications of these techniques, such as forensic genetics, genetic screening, and genetic engineering. Social impacts and ethical implications of these applications. This course is designed for nonbiology students and does not satisfy a lower-division requirement for any biology major. Open to nonbiology majors only. Exclude the following major codes: BI28, BI29, BI30, BI31, BI32, BI33, BI34, BI35, BI36. Note: Students may not receive credit for BILD 20 after receiving credit for BICD 100.

BILD 22. Human Nutrition (4)

A survey of our understanding of the basic chemistry and biology of human nutrition; discussions of all aspects of food: nutritional value, diet, nutritional diseases, public health, and public policy. This course is designed for nonbiology students and does not satisfy a lower-division requirement for any biology major. Open to nonbiology majors only. Exclude the following major codes: BI28, BI29, BI30, BI31, BI32, BI33, BI34, BI35, BI36. Note: Students may not receive credit for BILD 22 after receiving credit for BIBC 120.

BILD 26. Human Physiology (4)

Introduction to the elements of human physiology and the functioning of the various organ systems. The course presents a broad, yet detailed, analysis of human physiology, with particular emphasis towards understanding disease processes. This course is designed for nonbiology students and does not satisfy a lower-division requirement for any biology major. Open to nonbiology majors only. Exclude the following major codes: BI28, BI29, BI30, BI31, BI32, BI33, BI34, BI35, BI36. Note: Students may not receive credit for BILD 26 after receiving credit for BIPN 100.

BILD 36. AIDS Science and Society (4)

An introduction to all aspects of the AIDS epidemic. Topics will include the epidemiology, biology, and clinical aspects of HIV infection; HIV testing; education and approaches to therapy; and the social, political, and legal impacts of AIDS on the individual and society. This course is designed for nonbiology students and does not satisfy a lower-division requirement for any biology major. Open to nonbiology majors only. Exclude the following major codes: BI28, BI29, BI30, BI31, BI32, BI33, BI34, BI35, BI36. Note: Students may not receive credit for BILD 36 after receiving credit for BICD 136.

BILD 38. Dementia, Science, and Society (4)

Introduction to basic human neuroscience leading to a discussion of brain diseases classified under the rubric Dementia. Topics include basic brain structure and function, diseases of the aging brain and their economic, social, political and ethical impacts on society.

BILD 60. Race, Ethnicity, and Gender in Biology and Medicine (2)

This course will examine the practice and philosophy of science from a multicultural perspective; the historical use and misuse of science in biomedical research and social policies; and issues of race, ethnicity, and gender in biology and medicine in a postgenomic age. P/NP grades only. Recommended preparation: Students should have completed BILD 1, 2, and 3, or equivalent, prior to enrolling.

BILD 87. Freshman Seminar (1)

The Freshman Seminar Program is designed to provide new students with the opportunity to explore an intellectual topic with a faculty member in a small seminar setting. Freshman Seminars are offered in all campus departments and undergraduate colleges, and topics vary from quarter to quarter. Enrollment is limited to fifteen to twenty students, with preference given to entering freshmen.

BILD 91. Biology Freshmen: Strategies for Success (1)

Course is designed to assist new freshmen in making a smooth and informed transition from high school. Lectures focus on study skills, academic planning and using divisional and campus resources to help achieve academic, personal and professional goals. Exercises and practicums will develop the problems solving skills needed to succeed in biology. Attention will be given to research possibilities. Intended for new freshmen.

BILD 92. Professional Development Topics in the Biological Sciences (1)

Seminars will introduce students to various professional development topics in the biological sciences. Emphasis may include current research in academe and industry, using campus and community resources to help achieve academic, personal and professional goals, and career exploration. Activities may include presentations by faculty, alumni, and practicing professional biologists, as well as panel discussions with professionals from industry.

BILD 94. Professional Issues in Bioinformatics (1)

This seminar will introduce undergraduate students, especially freshmen and sophomores, to a variety of issues and topics in the field of bioinformatics.

BILD 95. Undergraduate Workshops (1)

The workshops will be restricted to lower-division undergraduates. The course will introduce students to the methods of scientific research and to a variety of research topics in the biological/biomedical sciences. Examples of topics are: Introduction to Scientific Research, AIDS, Medical and Social Aspects, Is the Mind the Same as the Brain, Wildlife Conservation.

BILD 96. Biology: Honors Seminar (2)

Weekly seminar providing Biological Sciences Scholars Program students with the opportunity to learn more about research and scholarly activities available to them, and acquaints them with UC San Diego faculty members. The course will promote student’s participation in research and other scholarly activities on campus. Departmental approval only (department will preauthorize students to enroll).

BILD 99. Independent Research (2 or 4)

Independent research by special arrangement with a faculty member. (P/NP grades only.) Students must have an overall UC San Diego GPA of at least 3.0 and a minimum of thirty units complete. Students must complete a Special Studies form and a Division of Biological Sciences Research Plan. Credit may not be received for a course numbered 99 subsequent to receiving credit for a course numbered 199.

Upper Division

Biochemistry

BIBC 100. Structural Biochemistry (4)

The structure and function of biomolecules. Includes protein conformation, dynamics, and function; enzymatic catalysis, enzyme kinetics, and allosteric regulation; lipids and membranes; sugars and polysaccharides; and nucleic acids. Prerequisites: Chem 140A and Chem 140B. (Note: Students may not receive credit for both BIBC 100 and Chem 114A.)

BIBC 102. Metabolic Biochemistry (4)

Energy-producing pathways–glycolysis, the TCA cycle, oxidative phosphorylation, photosynthesis, and fatty acid oxidation; and biosynthetic pathways–gluconeogenesis, glycogen synthesis, and fatty acid biosynthesis. Nitrogen metabolism, urea cycle, amino acid metabolism, nucleotide metabolism, and metabolism of macromolecules. Prerequisites: Chem 140A and Chem 140B. (Note: Students may not receive credit for both BIBC 102 and Chem 114B.)

BIBC 103. Biochemical Techniques (4)

Introductory laboratory course in current principles and techniques applicable to research problems in biochemistry and molecular biology. Techniques include protein and nucleic acid purification; identification methods such as centrifugation, chromatography, and electrophoresis; immunological, spectrophotometric, and enzymatic methods. Prerequisites: BILD 1. Students may not receive credit for BIBC 103 after taking Chem 112A (renumbered to Chem 108). Attendance at the first lecture/lab is required. Nonattendance will result in the student’s being dropped from the course roster.

BIBC 120. Nutrition (4)

Elaborates the relationship between diet and human metabolism, physiology, health, and disease. Covers the functions of carbohydrates, lipids, proteins, vitamins, and minerals, and discusses dietary influences on cardiovascular disease, diabetes, obesity, and cancer. Prerequisites: BIBC 102.

BIBC 140. Introduction to Biofuels (4)

Course will provide an overview of the growing field of biofuels by introducing the basics of renewable biofuel production, including the chemistry of biofuels, the biology of important feedstocks, and the biochemical advances for the next generation of biofuels. Prerequisites: BILD 1.

BIBC 194. Advanced Topics in Modern Biology: Biochemistry (2)

Course will vary in title and content. Students are expected to actively participate in course discussions, read, and analyze primary literature. Current descriptions and subtitles may be found on the Schedule of Classes and the Division of Biological Sciences website. Students may receive credit in 194 courses a total of four times as topics vary. Students may not receive credit for the same topic. Prerequisites: BIBC 100 or BIBC 102.

Genetics, Cellular and Developmental Biology of Plants and Animals

BICD 100. Genetics (4)

An introduction to the principles of heredity emphasizing diploid organisms. Topics include Mendelian inheritance and deviations from classical Mendelian ratios, pedigree analysis, gene interactions, gene mutation, linkage and gene mapping, reverse genetics, population genetics, and quantitative genetics. Prerequisites: BILD 1.

BICD 110. Cell Biology (4)

The structure and function of cells and cell organelles, cell growth and division, motility, cell differentiation and specialization. Prerequisites: BIBC 100 or BIBC 102.

BICD 120. Fundamentals of Plant Biology (4)

Introduction to the biology of plants. Basic principles of plant anatomy, physiology, development, and diversity will be covered as well as specialized topics, including plant genetic engineering, plant disease and stress, plants and the environment, and sustainable agriculture. Prerequisites: BILD 1 and BILD 2 or BILD 3.

BICD 123. Plant Molecular Genetics and Biotechnology Laboratory (6)

Techniques in plant cell and tissue culture, plant transformation, genetic selection and screening of mutants, host pathogen interactions, gene regulation, organelle isolation, membrane transport. Prerequisites: upper-division standing; BICD 120 strongly recommended. Attendance at the first lecture/lab is required. Nonattendance will result in the student’s being dropped from the course roster.

BICD 130. Embryos, Genes, and Development (4)

Developmental biology of animals at the tissue, cellular, and molecular levels. Basic processes of embryogenesis in a variety of invertebrate and vertebrate organisms. Cellular and molecular mechanisms that underlie cell fate determination and cell differentiation. More advanced topics such as pattern formation and sex determination are discussed. Open to upper-division students only. Prerequisites: upper-division standing; BICD 100; BIBC 100 or BIBC 102; BICD 110 strongly recommended, BIMM 100 strongly recommended.

BICD 134. Human Reproduction and Development (4)

This course is addressed to the development of the human sexual system, including gametogenesis, fertilization, and embryo implantation. Emphasis is placed on the physiology of reproductive functions. Prerequisites: BIBC 102 and BICD 100.

BICD 136. AIDS Science and Society (4)

An introduction to all aspects of the AIDS epidemic. Topics will include the epidemiology, biology, and clinical aspects of HIV infection, HIV testing, education and approaches to therapy, and the social, political, and legal impacts of AIDS on the individual and society. In order to count for their major, biology majors must take the upper-division course, BICD 136. Prerequisites: BILD 1, BILD 2 recommended.

BICD 140. Immunology (4)

Formation and function of the mammalian immune system, molecular and cellular basis of the immune response, infectious diseases and autoimmunity. Prerequisites: BICD 100, BIMM 100. BIBC 100 recommended.

BICD 145. Laboratory in Molecular Medicine (4)

This course focuses upon a molecular and immunological approach to study problems in modern medical research. The emphasis will be on novel approaches in medicine, including lymphocyte biology, cancer biology, and gene transfer. Material lab fee will apply. Prerequisites: BIMM 100. Attendance at the first lecture/lab is required. Nonattendance will result in the student’s being dropped from the course roster.

BICD 150. Endocrinology (4)

Normal function and diseases of the major hormone systems of the body including the hypothalamus/pituitary axis, the thyroid gland, reproduction and sexual development, metabolism and the pancreas, bone and calcium metabolism, and the adrenal glands. Prerequisites: BIPN 100 (may be taken concurrently).

BICD 194. Advanced Topics in Modern Biology: Cellular Development (2)

Course will vary in title and content. Students are expected to actively participate in course discussions, read, and analyze primary literature. Current descriptions and subtitles may be found on the Schedule of Classes and the Division of Biological Sciences website. Students may receive credit in 194 courses a total of four times as topics vary. Students may not receive credit for the same topic. Prerequisites: BICD 110.

Ecology, Behavior, and Evolution

BIEB 100. Biostatistics (4)

An interactive introduction to statistical inference and hypothesis testing. Emphasis on the conceptual and logical basis of statistical methods. Topics include describing data, generating hypotheses, sampling, significance, and randomization. The computer language R will be used. Mandatory weekly section. Prerequisites: BILD 3 and Math 10A or 20A and Math 10B or 20B. Students may not receive credit for both BIEB 100 and SIO 187.

BIEB 102. Introductory Ecology-Organisms and Habitat (4)

This course emphasizes principles shaping organisms, habitats, and ecosystems. Topics covered include population regulation, physiological ecology, competition, predation, and human exploitation. This will be an empirical look at general principles in ecology and conservation with emphasis on the unique organisms and habitats of California. Prerequisites: BILD 3 or equivalent.

BIEB 121. Ecology Laboratory (4)

A laboratory course to familiarize students with ecological problem solving and methods. Students will perform outdoor fieldwork and use a computer for data exploration and analysis. Prerequisites: BIEB 100. Attendance at the first lecture/lab is required. Nonattendance will result in the student’s being dropped from the course roster.

BIEB 126. Plant Ecology (4)

This course begins with an introduction to plant population biology including whole-plant growth and physiology. We then focus on three classes of ecological interactions: plant-plant competition, plant-herbivore coevolution, and plant reproductive ecology including animal pollination and seed dispersal. Prerequisites: BILD 3.

BIEB 128. Insect Ecology (4)

This course begins with a survey of insect diversity and phylogenetic relationships. We then address ecological issues including thermal ecology, population dynamics (including outbreaks), movement and migration, competition, predation, herbivory, parasitism, insect defense, mimicry complexes, and sociality. Prerequisites: BILD 3 or equivalent.

BIEB 130. Marine Conservation Biology (4)

Course integrates principles of ecology and marine biology to examine marine biodiversity loss resulting from over-exploitation, habitat loss, invasion, climate change, and pollution. Course examines consequences of biodiversity loss to marine ecosystems and discusses the efficacy of various management regimes. Conservation problems facing the world’s oceans with an emphasis on issues important for coastal California will be discussed. Prerequisites: BILD 3.

BIEB 131. Marine Invertebrate Ecology Lab (4)

A laboratory course introducing students to coastal marine ecology. Students will participate in outdoor fieldwork and work in the laboratory gathering and analyzing ecological data. We will focus on ecological communities from a variety of coastal habitats and use them to learn about basic ecological processes as well as issues related to sustainability and conservation of biodiversity. Fieldwork is expected in this course. Associated travel in the San Diego area is required and students are responsible for their own transportation. Material lab fee may apply. Prerequisites: BILD 3 and BIEB 100.

BIEB 135. Aquatic Ecology Lab (4)

Course provides overview of physical, chemical, and biological processes that characterize inland waters (lakes and rivers), estuaries, and near-shore environments. Dominant biota of lakes, rivers, and streams, and how they are related to physical and chemical processes of the systems in which they reside will be covered. Methods will be introduced for assessing the chemical composition of water and detecting organisms that affect drinking water quality and coastal water quality management. Course requires field studies. Students should expect to fully participate in field trips; transportation not provided by the university. Students must comply with all risk management policies/procedures. Course material fee will be applied. Prerequisites: BILD 3.

BIEB 140. Biodiversity (4)

An introduction to the patterns of geographic distribution and natural history of plants and animals living in terrestrial and marine ecosystems. We will explore: ecological and evolutionary processes responsible for generating and maintaining biological diversity; and the nature of extinction both in past and present ecosystem. Prerequisites: BILD 3.

BIEB 143. Computer Modeling in Evolution and Ecology (4)

An introduction to computer modeling in evolution and ecology. Students will use the computer language Python to write code to analyze ecological and evolutionary processes. Topics include natural selection, genetic drift, community ecology, game theory, and chaos. Students will use their own laptop computers. Prerequisites: BIEB 100 or BIEB 150.

BIEB 150. Evolution (4)

Evolutionary processes are discussed in their genetic, historical, and ecological contexts. Population genetics, agents of evolution, microevolution, speciation, macroevolution. Prerequisites: BILD 3 and BILD 1 or BIEB 143.

BIEB 166. Animal Behavior and Communication (4)

An integrated approach to animal behavior focusing on mechanisms of acoustic, visual, and olfactory communication. Course covers ethology and the genetics and neurobiology of behavior; orientation and navigation; and signal origins, properties, design, and evolution. Prerequisites: BILD 3 and Physics 1A or 2A.

BIEB 167. Animal Communication Lab (4)

Laboratory exercises will introduce students to quantitative methods of visual, auditory, and olfactory signal analysis and to lab and field studies of animal signaling. Prerequisites: BIEB 100 and BIEB 166. Attendance at the first lecture/lab is required. Nonattendance will result in the student’s being dropped from the course roster. Material fee will apply.

BIEB 174. Ecosystems and Global Change (4)

Course will teach the principles of terrestrial ecosystem ecology, and will use examples from recent research to help students understand how global environmental changes are altering processes from leaf-level ecophysiology to global cycling of carbon, water, and nutrients. Fieldwork may be required. Prerequisites: BILD 3.

BIEB 176. Conservation and the Human Predicament (4)

Interdisciplinary discussion of the human predicament, the biodiversity crisis, and the importance of biological conservation. Examines issues from biological, cultural, historical, economic, social, political, and ethical perspectives emphasizing new approaches and new techniques for safeguarding the future of humans and other biosphere inhabitants. Prerequisites: ANLD 2 or BILD 3 or ANTH 2 or consent of instructor.

BIEB 194. Advanced Topics in Modern Biology: Ecology, Behavior, Evolution (2)

Course will vary in title and content. Students are expected to actively participate in course discussions, read, and analyze primary literature. Current descriptions and subtitles may be found on the Schedule of Classes and the Division of Biological Sciences website. Students may receive credit in 194 courses a total of four times as topics vary. Students may not receive credit for the same topic. Prerequisites: BIEB 102.

Molecular Biology, Microbiology

BIMM 100. Molecular Biology (4)

Molecular basis of biological processes, emphasizing gene action in context of entire genome. Chromosomes and DNA metabolism: chromatin, DNA replication, repair, mutation, recombination, transposition. Transcription, protein synthesis, regulation of gene activity. Procaryotes and eukaryotes Prerequisites: BIBC 100 or BIBC 102, BICD 100. (Note: Students may not receive credit for both BIMM 100 and Chem 114C.)

BIMM 101. Recombinant DNA Techniques (4)

Theory and practice of recombinant DNA and molecular biology techniques. Includes construction and screening of DNA libraries, DNA sequencing, PCR and its applications, bioinformatics, and RNA analysis. Nonattendance will result in the student’s being dropped from the course roster. Recommended preparation: BIMM 100. Students may not enroll in or receive credit for both BIMM 101 and BIEB 123, or BIMM 101 and Chem 109 (formerly Chem 112B). Prerequisites: BILD 1.

BIMM 108. Adventures in Chromatin Structure and Gene Expression (4)

Chromatin, the natural state of DNA in eukaryotes, has recently emerged as a critical component of many important biological processes. Topics include histone modifications, chromatin dynamics, transcription factors, enhancers, CpG methylation, heterochromatin, epigenetics, and the role of chromatin in human biology. Prerequisites: BIMM 100.

BIMM 110. Molecular Basis of Human Disease (4)

An examination of the molecular basis of human diseases. Course emphasizes inherited human disorders, and some important diseases caused by viruses. Focus on the application of genetic, biochemical, and molecular biological principles to an understanding of the diseases. Course restricted to upper-division biology majors. Prerequisites: BICD 100; BIBC 102; BIMM 100.

BIMM 112.Regulation of Eukaryotic Gene Expressions (4)

This course explores the mechanisms by which gene activity is regulated in eukaryotes, with an emphasis on transcriptional regulation and chromatin. Topics will include chromatin structure, histone modifications, chromatin dynamics, transcription factors, transcriptional elongation, enhancers, CpG methylation, heterochromatin, and epigenetics. Prerequisites: BIMM 100.

BIMM 114. Virology (4)

An introduction to eukaryotic virology, with emphasis on animal virus systems. Topics discussed include the molecular structure of viruses; the multiplication strategies of the major virus families; and viral latency, persistence, and oncology. Prerequisites: BIMM 100.

BIMM 116. Circadian Rhythms—Biological Clocks (4)

(Cross-listed with Psych 133; however, biology majors must take the course as BIMM 116.) Examples and fundamental properties of the daily biological clock in humans, animals, and microbes. Experimental approaches employed to understand how organisms keep time and how this applies to human health. Prerequisites: BILD 1 or Psych 106 or consent of instructor.

BIMM 118. Pharmacology (4)

Basics of pharmacology such as drug absorption, distribution, metabolism, and elimination. Concepts in toxicology and pharmacognosy are used to survey the major drug categories. Prerequisites: BIBC 100 or BIBC 102; BIPN 100.

BIMM 120. Bacteriology (4)

A discussion of the structure, growth, molecular genetics, and physiology of procaryotic microorganisms, with emphasis on the diverse activities of bacteria and on the interaction of various bacterial species with their environment. Prerequisites: Chem 140A; Chem 140B; BIBC 100 or BIBC 102 (may be taken concurrently).

BIMM 121. Laboratory in Microbiology (4)

Course emphasizes fundamental principles of microbiology, including comparative bacterial morphology and physiology, pure culture techniques, and bacterial growth. Additional studies include bacteriophage interactions, antibiotics, the use of bio-assays, natural microbial communities through metagenomics and enrichment, and bacteria in biotechnology. Material lab fee will apply. Attendance at the first lecture/lab is required. Nonattendance will result in the student’s being dropped from the course roster. Prerequisites: BILD 1 and BIBC 102 .

BIMM 122. Microbial Genetics (4)

Course will consider the organization and function of prokaryotic genomes including content, DNA supercoiling, histone-like proteins, chromosomal dynamics (short-term and long-term), extrachromosomal elements, bacterial sex, transduction, transformation, mobile elements (transposon), epigenetic change, adaptive and directed mutation, transcription and its regulation, sensory transduction, bacterial differentiation, symbiosis, and pathogenesis. Prerequisites: BIMM 100.

BIMM 124. Medical Microbiology (4)

Encompasses the increasingly important areas of viral, bacterial, and parasitic diseases and understanding the complex interaction between humans and infectious agents. Covers human-pathogen interactions, mechanisms and molecular principles of infectious diseases, immune responses, countermeasures by pathogens and hosts, epidemiology, and cutting-edge approaches to therapy. Prerequisites: BIBC 100 or BIBC 102.

BIMM 130. Microbial Physiology (4)

Prokaryotic cell biology will be discussed primarily from physiological and biochemical standpoints with a focus on conceptual understanding, integration, and mechanism. Topics will vary from year to year but will include the following themes: bioenergetics, cell polarity, cell adhesion, the molecular basis of morphogenesis and differentiation, prokaryotic motility and behavior, rotary and linear molecular machines, bacterial organelles, pheromones and messengers, circadian rhythms, biological warfare, and bioremediation. Prerequisites: BIBC 100 or BIBC 102.

BIMM 134. Biology of Cancer (4)

This course covers basic processes of transformation and tumor formation in a two-part format. The first section is focused on molecular and cellular mechanisms of carcinogenesis. The second section discusses tumor pathology and metastasis. Open to upper-division students only. Prerequisites: BICD 110 and BIMM 100.

BIMM 149. Computation for Biologists (4)

Course will provide students with the computational tools and problem-solving skills that are increasingly important to the biosciences. Students learn to program in a modern general-purpose programming language and write their own programs to explore a variety of applications in biology including simulations, sequence analysis, phylogenetics, among others. Students will use their own laptop computers. Prerequisites: BILD 1 and BILD 2.

BIMM 162. 3D Electron Microscopy of Macromolecules (4)

Biological macromolecules and supramolecular complexes, organelles, and small cells are being examined in three-dimensions by modern electron cryomicroscopy and image reconstruction techniques. The basic principles of transmission electron microscopy and 3D image reconstruction are discussed. Prerequisites: Chem 114A or BIBC 100 or BIBC 110 and Physics 1C or 2C or 2D; upper-division standing.

BIMM 164. Structural Biology of Viruses (4)

An introduction to virus structures, how they are determined, and how they facilitate the various stages of the viral life cycle from host recognition and entry to replication, assembly, release, and transmission to uninfected host cells. Prerequisites: BIBC 100 or Chem 114A; upper-division standing.

BIMM 171. Genomics Research Initiative (1)

This class will examine the theoretical and practical basis of modern genomics research. Students will learn the theoretical basis of genomics and tools used for the sequencing and annotation of genomic DNA, and computational and molecular methods for the study of evolution. Prerequisites: departmental approval required (department will preauthorize students to enroll). Restricted to students participating in the National Genomics Research Initiative Program.

BIMM 171A. Genomics Research Initiative Laboratory I (4)

Students will isolate bacterial viruses or other organisms from the environment and characterize them by methods including electron microscopy and nucleic acid analysis. The genomic DNA will be purified, and sent for sequencing. Prerequisites: departmental approval required. Restricted to students participating in the National Genomics Research Initiative Program.

BIMM 171B. Genomics Research Initiative Laboratory II (4)

Students will characterize the genomic sequence of the organisms isolated in BIMM 171A and use molecular and computational tools to resolve ambiguities and close gaps. They will then annotate the DNA sequence to identify protein and RNA coding regions. Prerequisites: BIMM 171 and BIMM 171A.

BIMM 171C. Genomics Research Initiative Laboratory III (4)

Computational methods will be used to characterize the annotated genome sequence produced in BIMM 171A-B to study the evolution of genes and their products. Various mechanisms shaping genome evolution will be discussed and the genome evaluated for evidence of these processes. Prerequisites: BIMM 171, BIMM 171A, and BIMM 171B.

BIMM 181. Molecular Sequence Analysis (4)

This course covers the analysis of nucleic acid and protein sequences, with an emphasis on the application of algorithms to biological problems. Topics include sequence alignments, database searching, comparative genomics, and phylogenetic and clustering analyses. Pairwise alignment, multiple alignment, DNA sequencing, scoring functions, fast database search, comparative genomics, clustering, phylogenetic trees, gene finding/DNA statistics. This course open to bioinformatics majors only. Prerequisites: CSE 100 or Math 176, CSE 101 or Math 188, BIMM 100 or Chem 114C.

BIMM 182. Biological Databases (4)

This course provides an introduction to the features of biological data, how that data are organized efficiently in databases, and how existing data resources can be utilized to solve a variety of biological problems. Object-oriented databases, data modeling and description, survey of current biological database with respect to above, implementation of database focused on a biological topic. This course open to bioinformatics majors only. Prerequisites: CSE 100 or Math 176.

BIMM 184. Computational Molecular Biology (4)

This advanced course covers the application of machine learning and modeling techniques to biological systems. Topics include gene structure, recognition of DNA and protein sequence patterns, classification, and protein structure prediction. Pattern discovery, hidden Markov models/support vector machines/neural network/profiles, protein structure prediction, functional characterization of proteins, functional genomics/proteomics, metabolic pathways/gene networks. Prerequisites: BIMM 181 or BENG 181 or CSE 181, BIMM 182 or BENG 182 or CSE 182 or Chem 182.

BIMM 185. Bioinformatics Laboratory (Advanced) (4)

This course emphasizes the hands-on application of bioinformatics methods to biological problems. Students will gain experience in the application of existing software, as well as in combining approaches to answer specific biological questions. Sequence alignment, fast database search, profiles and motifs, comparative genomics, gene finding, phylogenetic trees, protein structure, functional characterization of proteins, expression anaylysis, computational proteomics. This course open to bioinformatics majors only. Prerequisites: two courses out of BIMM 181 or BENG 181 or CSE 181, BIMM 182 or BENG 182 or CSE 182, BENG 183, BIMM 184 or BENG 184 or CSE 184. Attendance at the first lecture/lab is required. Nonattendance will result in the student’s being dropped from the course roster.

BIMM 194. Advanced Topics in Modern Biology: Molecular Biology (2)

Course will vary in title and content. Students are expected to actively participate in course discussions, read, and analyze primary literature. Current descriptions and subtitles may be found on the Schedule of Classes and the Division of Biological Sciences website. Students may receive credit in 194 courses a total of four times as topics vary. Students may not receive credit for the same topic. Prerequisites: BIMM 100.

Physiology and Neuroscience

BIPN 100. Human Physiology I (4)

Course introduces the concepts of physiological regulation, controlled and integrated by the nervous and endocrine systems. Course then examines the muscular, cardiovascular, and renal systems in detail and considers their control through the interaction of nervous activity and hormones. Students may not receive credit for both BIPN 100 and BENG 140A. Prerequisites: BILD 1 and BILD 2.

BIPN 102. Human Physiology II (4)

Course completes a survey of organ systems begun in BIPN 100 by considering the respiratory and gastrointestinal systems. Consideration is given to interactions of these systems in weight and temperature regulation, exercise physiology, stress, and pregnancy and reproduction. Students may not receive credit for both BIPN 102 and BENG 140B. Prerequisites: BIPN 100.

BIPN 105. Animal Physiology Lab (6)

Experiments are performed on membrane physiology, nerve and muscle function, hormone actions, cardiovascular physiology, and renal function. Subjects include experimental animals. Students will perform a research project and present their results in a symposium at the end of the quarter. Prerequisites: BIPN 100. Attendance at the first lecture/lab is required. Nonattendance will result in the student’s being dropped from the course roster. Material fee will apply.

BIPN 106. Comparative Physiology (4)

This course examines the physiological adaptation of animals, invertebrates and vertebrates, to their particular environmental and behavioral niches. Structural, functional, and molecular adaptations of the basic organ systems are discussed. Prerequisites: BILD 2, Chem 6A-B-C. BILD 3 is recommended.

BIPN 108. Physiology of Exercise (4)

Course addresses the human body’s response to exercise, addressing energy metabolism and the effects of both acute and chronic exercise on function in several important organ systems. Designing training regimes and the role of exercise in health will be considered. Prerequisites: BIPN 100 required; BIPN 102 and BIBC 102 recommended.

BIPN 140. Cellular Neurobiology (4)

This course covers the biophysics of the resting and active membranes of nerve cells. It also covers the mechanisms of sensory transduction and neuromodulation, as well as the molecular basis of nerve cell function. Prerequisites: BILD 1, 2; BIBC 100 or 102 recommended.

BIPN 142. Systems Neurobiology (4)

Course will cover integrated networks of nerve cells, including simple circuits like those involved in spinal reflexes.  Course will study how information and motor output is integrated and processed in the brain. Course will also discuss higher-level neural processing. Prerequisites: BIPN 100 or BIPN 140.

BIPN 144. Developmental Neurobiology (4)

Molecular basis of neuronal cell fate determination, axon pathfinding, synaptogenesis experience-based refinement of connections, and learning in the brain will be examined. Prerequisites: upper-division standing.

BIPN 146. Computational Neurobiology (4)

An exploration of computational brain models, including biophysical models of single neurons, small neural circuits, and larger scale network models. Prerequisites: BILD 12 or BIPN 140 or Psych 106 or Cog Sci 107 recommended.

BIPN 148. Cellular Basis of Learning and Memory (4)

Course will explore cellular and molecular mechanisms that underlie learning and memory. Topics will include synapse formation and synaptic plasticity, neurotransmitter systems and their receptors, mechanisms of synaptic modification, and effect of experience on neuronal connectivity, and gene expression. Prerequisites: BIPN 100.

BIPN 150. Diseases of the Nervous System (4)

Course will be taught from a research perspective, highlighting the biological pathways impacted by different neurological diseases. Each disease covered will be used to illustrate a key molecular/cellular pathway involved in proper neurological function. Prerequisites: BIBC 102 and BICD 100.

BIPN 152. The Healthy and Diseased Brain (4)

Coverage of the history of research, diagnosis, and treatment of common neuropsychiatric disorders. Comparisons will be made between primary research data and existing treatments, and on developing skills to digest scientific literature aimed at understanding the neuroscience of disease. Prerequisites: BILD 1 and BILD 2.

BIPN 194. Advanced Topics in Modern Biology: Physiology and Neuroscience (2)

Course will vary in title and content. Students are expected to actively participate in course discussions, read, and analyze primary literature. Current descriptions and subtitles may be found on the Schedule of Classes and the Division of Biological Sciences website. Students may receive credit in 194 courses a total of four times as topics vary. Students may not receive credit for the same topic. Prerequisites: BIPN 100 or BIPN 140.

Special Courses

BISP 170. Bioscholars Seminar: From Bench to Bedside and Beyond (2)

Course will examine different aspects of a recent topic in biology. Seminar will begin with an examination of the scientific foundation of the chosen theme (bench) and proceed to address the relevant applications of the subject in the medical field (bedside) and current key societal challenges of global dimensions (beyond), all of which will be framed within a consideration of diverse perspectives. Prerequisites: BILD 1 and BILD 2.

BISP 190. Advanced Biology Seminars for Seniors (2)

Experts in diverse areas of biology from major universities in the U.S. and abroad will describe current research activities conducted in their laboratories. Relevant readings will be assigned. P/NP grades only. Prerequisites: seniors only; concurrent enrollment in BISP 199 or consent of instructor.

BISP 191. Biology Transfers: Strategies for Success (1)

Course is designed to assist new transfers in making a smooth and informed transition from community college. Lectures focus on study skills, academic planning and using divisional and campus resources to help achieve academic, personal and professional goals. Exercises and practicums will develop the problem solving skills needed to succeed in biology. Attention will be given to research possibilities. Intended for new transfers. Prerequisites: upper-division standing.

BISP 192. Senior Seminar in Biology (1)

The Senior Seminar Program is designed to allow senior undergraduates to meet with faculty members in a small group setting to explore an intellectual topic in biology (at the upper-division level). Topics will vary from quarter to quarter. Senior Seminars may be taken for credit up to four times, with a change in topic and permission of the department. Enrollment is limited to twenty students, with preference given to seniors. Prerequisites: upper-division standing; department stamp and/or consent of instructor.

BISP 194. Advanced Topics in Modern Biology (2)

Course will vary in title and content. Students are expected to actively participate in course discussions, read, and analyze primary literature. Current descriptions and subtitles may be found on the Schedule of Classes and the Division of Biological Sciences website. Students may receive credit in 194 courses a total of four times as topics vary. Students may not receive credit for the same topic. Prerequisites: BICD 100; upper-division standing.

BISP 195. Introduction to Teaching in Biology (4)

Introduction to the teaching of the basic course in biology. A student under the direction of the instructor of the course is assigned one class section and will meet one time per week with the section. A student is required to attend the course lecture, lead a discussion section, and meet with the instructor of the course at least one time per week. Limited to upper-division students who have a B average or higher. Three hours’ lecture. (P/NP grades only.) Prerequisites: consent of instructor and approval of department chair. (Note: Applications for a BISP 195 are to be submitted to the Division of Biological Sciences by the end of the sixth week of the quarter preceding the quarter in which the BISP 195 will be completed.) This course may be counted as one of the upper-division electives for a biology major.

BISP 196. Honors Thesis in Biological Sciences(4)

Course for student participants in the senior Honors thesis research program. Students complete individual research on a problem by special arrangement with, and under the direction of, a faculty member. Projects are expected to involve primary, experimental/analytical approaches that augment training in basic biology and that echo the curricular focus of the Division of Biological Sciences. P/NP grades only. May be taken for credit three times. Research to be approved by Honors thesis faculty adviser via application. Prerequisites: Students must have senior standing; 3.6 overall and major GPA or above. Research must be approved by Honors thesis faculty adviser. Enrollment in this course is for those students participating in the Honors Program in Biological Sciences and is via departmental approval only.

BISP 197. Biology Internship Program (4)

Individual research on a problem by special arrangement with, and under the direction of, a UC San Diego faculty member and a selected researcher in industry or at a research institution. Projects are expected to involve primary, experimental/analytical approaches that augment training in basic biology and that echo the curricular focus of the Division of Biological Sciences. Application/research plan due by Friday of the tenth week of the quarter preceding the quarter in which the 197 course will be completed. Students must comply with all risk management policies/procedures. P/NP grades only. May be taken for credit three times. Prerequisites: department approval required. Students must complete at least ninety units of credit and have a minimum GPA of 2.5. A completed and approved Division of Biological Sciences application/research plan is required for enrollment.

BISP 199. Individual Research for Undergraduates (2 or 4)

Individual research on a problem by special arrangement with, and under the direction of, a faculty member. Projects are expected to involve primary, experimental/analytical approaches that augment training in basic biology and that echo the curricular focus of the Division of Biological Sciences. P/NP grades only. May be taken for credit five times. Prerequisites: Department approval required. Students must complete at least ninety units of credit and have a minimum GPA of 2.5. A completed and approved Special Studies form and a Division of Biological Sciences research plan is required for enrollment. Students must complete a Special Studies application as well as a research plan. Paperwork for a BISP 199 must be submitted to SIS by Friday of the eighth week of the quarter preceding the quarter in which the 199 course will be completed.

Graduate

BGGN 200. Graduate School Fundamentals: Introduction to Graduate Studies in the Division of Biological Sciences (2)

Course will cover fundamental issues in academia, including campus resources, research design, ethical issues in research, scientific publishing and review, grant preparation, etc. Required of all first year PhD students in the Division of Biological Sciences. Prerequisites: graduate (PhD) standing only; for students in the following major code BI77, or consent of instructor. (S/U grades only.) (F)

BGGN 201. Methods in Computational Neuroscience (3)

Introduction to the computational methods most frequently used in neuroscience research. Aimed at first year graduate students in neuroscience and related disciplines. Minimal quantitative background will be assumed. Topics include Poisson processes, Markov Chains, auto- and cross-correlation analysis, Fourier/Spectral analysis, principal components/linear algebra, signal detection theory, information theory, Bayes Theorem, hypothesis testing. Nongraduate students may enroll with consent of instructor.

BGGN 204. Topics in Community and Population Ecology (3)

This course teaches a different topic each quarter on the theoretical or conceptual side of community and population ecology. Students will read materials in depth, attend weekly discussions, and explore theories and models with statistical, analytical, and algorithmic tools of the trade. Prerequisites: graduate standing or consent of instructor. (S/U grades only.) (Quarter offered varies and course is not offered every year.)

BGGN 205. Communicating Science to the Public (2)

Learn effective ways of communicating science to nonscientists. Develop an understanding of how people’s views of science and background knowledge can influence their learning, and develop methods to tailor communication for different audiences. (Quarter offered varies, and course is not offered every year.)

BGGN 206. Topics in Biophysics and Physical Biochemistry (4)

Selection of topics of current interest. Examples: primary processes of photosynthesis; membrane biophysics; applications of physical methods to problems in biology and chemistry, e.g., magnetic resonance, X-ray diffraction, fluctuation spectroscopy, optical techniques (fluorescence, optical rotary dispersion, circular dichroism). Topics may vary from year to year. Prerequisites: consent of instructor. (S/U grades permitted.) This course is cross-listed with Physics 206 and Chemistry 206. (Quarter offered varies, and course is not offered every year.)

BGGN 208. Biological Sciences Graduate Boot Camp (4)

Intensive lecture-, seminar-, and laboratory-based course for incoming first year students in the biological sciences PhD program. Topics covered: evolution and quantitative biology, including biostatistics, image analysis, bioinformatics, genomics, evolution, analysis of DNA proteins. During the first two weeks in September, students commit to ten to fifteen hours per day. Prerequisites: graduate (PhD) standing only; for students in the following major code BI77. (S/U grades only.) (F)

BGGN 210. Neurobiology Boot Camp (4)

For incoming doctoral students in neurobiology, computational neurobiology, and neurosciences. During first two weeks in September, students commit to ten to fifteen hours per day in lectures and laboratories in electrophysiology, cellular anatomy, molecular biology, optical imaging, and computational neurobiology. Students also attend weekly seminars during fall quarter. Prerequisites: graduate standing; major codes BI77, BI79, NE75. (F)

BGGN 211. Recent Advances and Experimental Approaches in Modern Biology (4)

Introduces students to advanced concepts of modern biology (e.g. molecular and cell biology, biochemistry, genomics, and epigenomics, etc.). Current experimental approaches (including high-throughput sequencing, microarray technology, RNAi, proteomic technologies, ChIP-seq) are discussed using primary research papers. The course provides training in critical analysis of scientific papers, data interpretation, scientific writing, and experimental design. Prerequisites: for MS students only in the following major code BI77 (letter grades only).

BGGN 212. Special Topics in Microbiology (3)

Recent developments in prokaryotic and eukaryotic microbial research. Topics vary from year to year but may include the following subjects: the molecular basis of (a) sex determination, expression, and interconversion; (b) differentiation, morphogenesis, and programmed death; (c) transcriptional and metabolic regulation; and (d) chemical macromolecular and energy-mediated reception, transmission, and response processes. The main thesis of the course is that examples of complex regulatory phenomena in higher organisms can be found in single celled organisms. This course is open to enrollment by undergraduates. Prerequisites: BIBC 102 and BICD 100. (S/U grades permitted.) (Quarter offered varies, and course is not offered every year.)

BGGN 214. Introduction to Q-Biology (4)

The course goal is to discuss and work through examples where quantitative biology approaches were necessary to yield novel biological insights. Problems will be presented with a historic perspective to instill a philosophy for when, how, and why q-bio approaches are most effective. The course may also appeal to physics and engineering graduate students. S/U grades permitted. Prerequisites: graduate standing or consent of instructor. (Quarter offered varies, and course is not offered every year.)

BGGN 216. Graduate Biostatistics (4)

Fundamentals behind and practical application of biostatistics, including central tendency and variability, hypothesis testing, inferential techniques (parametric and nonparametric), correlation and regression. Practice examples taken from the laboratory bench and primary literature. Training in the use of biostatistical software. Prerequisites: graduate standing or consent of instructor. (W)

BGGN 217. Intervention in Human Disease States (2)

Students will learn how to distinguish between fact and fiction in treatment efficacy for serious human disease states in humans. The focus will be on evidence from research papers on various treatments. For CMG training program students. Prerequisites: graduate (PhD) standing only; for students in the following major code BI77; or consent of instructor. (Quarter offered varies.)

BGGN 218. Post-Genomics Biology (2)

This course will focus on large-scale analysis of post-genomics biological systems. Students will be introduced to methods for analyzing changes in gene expression, identifying protein-protein interactions, screening for pathway inhibitors, characterizing multiprotein complexes, and probing protein localization and function.

BGGN 220. Graduate Molecular Biology (6)

Provides a broad, advanced-level coverage of modern molecular biology for first-year graduate students. Topics include prokaryotic and eukaryotic gene structure and regulation, chromatin structure, DNA replication, translation, mechanisms of transcription, and an introduction to viruses. OPEN ONLY TO STUDENTS ENROLLED IN A GRADUATE DEGREE PROGRAM. (Letter grades only.) (F)

BGGN 221. Graduate Protein Biochemistry (4)

Topics include general aspects of protein structure and biochemical approaches to the isolation and study of proteins. This course also covers the relationship between the structure and function of selected proteins. Detailed discussion of modern biophysical methods to study protein-protein interactions will be included. BGGN 220 is a corequisite. OPEN ONLY TO STUDENTS ENROLLED IN A GRADUATE DEGREE PROGRAM. (Letter grades only.) Corequisite: BGGN 220. (F)

BGGN 222. Graduate Cell Biology (6)

A coverage of modern cell biology for first year graduate students. There is an up-to-date discussion of topics such as: structure and function of membranes; ion pumps, ion channels, transmembrane signaling; receptor mediated endocytosis; protein targeting; the role of RER and Golgi apparatus; the biosynthesis of intracellular organelles in animal and plant cells; the cytoskeleton, motility, molecular motors, cell-cell interactions, mitosis; and the control of cell division. Also included are extensive coverage of cell signaling mechanisms and discussions on molecular approaches to cell biology. Prerequisites: BGGN 220 and 221. OPEN ONLY TO STUDENTS ENROLLED IN A GRADUATE DEGREE PROGRAM. (Letter grades only.) (W)

BGGN 223. Graduate Genetics (6)

Provides a broad and extensive advanced-level coverage of molecular and formal aspects of genetics for first-year graduate students. Topics covered include: bacterial genetics, recombination in prokaryotes and eukaryotes, mammalian somatic-cell genetics, developmental genetics, sex determination, dosage compensation, and immunogenetics. Extensive coverage of the use of model systems like Drosophila and C. elegans is included. General and specific aspects of cellular signaling mechanisms will be covered. Prerequisites: BGGN 220, 221 and 222. OPEN ONLY TO STUDENTS ENROLLED IN A GRADUATE DEGREE PROGRAM. (Letter grades only.) (S)

BGGN 224. Graduate Neurobiology (4)

Course covers modern molecular, cellular, developmental, and physiological aspects of neurobiology. Extensive discussion of original research articles will be included. Prerequisites: BGGN 220 and 221. OPEN ONLY TO STUDENTS ENROLLED IN A GRADUATE DEGREE PROGRAM. (Letter grades only.) (F)

BGGN 225. Graduate Immunology (4)

The course is devoted to immunology and is organized as a combined lecture-tutorial course stressing classical as well as current literature. Each week will compose an independent section. Topics will include cellular interactions involved in the immune response and the molecular biology unique to lymphoid factor and receptors. Prerequisites: BGGN 220 and 221. OPEN ONLY TO STUDENTS ENROLLED IN A GRADUATE DEGREE PROGRAM. (Letter grades only.) (S)

BGGN 226. Graduate Animal Virology (4)

This course consists of a review of fundamental concepts together with an in-depth analysis of the structure, genetics, multiplication and oncogenicity of animal viruses. Particular emphasis will be given to the DNA and RNA tumor viruses. The format of this section includes lectures and discussion of selected papers. Prerequisites: BGGN 220 and 221. OPEN ONLY TO STUDENTS ENROLLED IN A GRADUATE DEGREE PROGRAM. (Letter grades only.) (W)

BGGN 227. Graduate Topics in Plant Biology (4)

This course covers advanced topics in plant biology in the areas of molecular genetic developmental, and physiological biology. We will discuss plant-microbe interactions, transposable elements, protein trafficking, ion transport, and organ development. The format of this section includes lectures and discussion of selected papers. Prerequisites: BGGN 220, 221, and 222. OPEN ONLY TO STUDENTS ENROLLED IN A GRADUATE DEGREE PROGRAM. (Letter grades only.) (W)

BGGN 228. Graduate Developmental Biology (4)

This course covers graduate level lectures on developmental biology, emphasizing the use of genetically tractable model systems. Discussion of recent research articles is an integral aspect of this course. Students are introduced to classical experiments and given detailed coverage of recent fundamental findings in developmental biology. Prerequisites: BGGN 220 and 221. (Letter grades only.) (S)

BGGN 230. Graduate Signal Transduction (4)

The course will introduce students to a variety of signal transduction pathways and their function in the regulation of cellular processes. Special emphasis will be given to signaling cascades regulating immunological responses and alterations of signaling pathways during oncogenesis. (W)

BGGN 231. Current Concepts in Stem Cell Biology (4)

Research papers from all aspects of stem cell biology will be read, presented, and discussed. Papers will range from landmark to current studies, spanning many developmental organisms and cell types. Students will present one paper, provide relevant background, and lead discussions. Prerequisites: graduate standing or consent of instructor. (F)

BGGN 233. Cellular Immunology (3)

This course covers the molecular and cellular events in the humoral and cellular response to antigen, transplantation biology, the structure and function of the major histocompatibility gene complex, the T-cell receptor, lymphokines, and the induction of immunological tolerance. It serves as the second course in a two-part sequence. May be taken by undergraduates who have taken Part 1 (BICD 140) and by graduate students (S/U grades only.) (Quarter offered varies and course is not offered every year.)

BGGN 234. Practical Histopathology and Mouse Models of Human Disease (2)

This course is designed to train those who need to analyze mouse models of human disease that are an essential part of their research. Sessions will include hematology, chemistry, histology, and immunohistochemistry methods used in the phenotyping assays. (Quarter offered varies and course is not offered every year.) (Cross-listed with PATH 234, MED 234, BIOM 238.) Prerequisites: standard undergraduate biology courses.

BGGN 235. Biology and Biochemistry of Cancer Cells (2)

This course covers recent advances in cell biology, biochemistry, immunology, and virology as they relate to cancer cells and their interaction with the host. Cancer research specialists from outside will be brought in to discuss the most recent evidence and interpretations in key areas of cancer research. This course meets two hours per week for lecture and discussion. It will be at an advanced graduate level but open to a limited number of seniors (with permission of instructor) on a P/NP basis. (S/U grades only.) (Quarter offered varies, and course is not offered every year.)

BGGN 238A. Integrative Microbiology I (4)

To introduce students with structural and functional properties of microorganisms and with the role of microbes in the world. Course will emphasize the integrative aspects of microbiology. First course in series. Prerequisites: graduate standing.

BGGN 238B. Integrative Microbiology II (4)

To introduce students with structural and functional properties of microorganisms and with the role of microbes in the world. Course will emphasize the integrative aspects of microbiology. Second course in series. Prerequisites: graduate standing.

BGGN 240. Cellular Neurobiology (2)

Students read classic and modern papers that form the basis of the undergraduate lectures (BIPN 240), which they are encouraged to attend. These papers are presented by the students at weekly discussion sessions. Prerequisites: consent of instructor. (S/U grades only.) (F)

BGGN 242. Graduate Cancer Biology (3)

Research-oriented approach to oncology topics and problems with an emphasis on interactions between tumor and the immune system. Prerequisites: graduate standing.

BGGN 243. Systems Neurophysiology (3)

Ways in which neurons are assembled into circuits to achieve perception and patterned movement. Prerequisites: graduate standing or consent of instructor. (S/U grades only.)

BGGN 245. Advanced Topics in Cancer Research and Therapy (2)

Lectures on basic and advanced concepts in cancer biology, will include defining outstanding contemporary questions and cutting-edge basic and translational research. Will rely on participants reading assigned literature prior to lectures. For PhD or MS students. Course will be held at the Salk Institute. (S/U grades only).

BGGN 246A. Computational Neurobiology (2)

Students read classic and modern papers that form the basis of the undergraduate lectures (BIPN 146), which they are encouraged to attend. Students present these papers at weekly discussion sessions. The focus of 246A is cellular neuronal properties. Prerequisites: graduate standing or consent of instructor. (S/U grades only.)

BGGN 248. Molecular Mechanisms of Neural Development (4)

This course will cover the cellular and molecular basis of neural development. Focus is on primary research papers and topics include neural induction and neurogenesis, cell patterning, neuronal and glial differentiation, neuronal migration, axon pathfinding, synapogenesis, neuronal cell death, regeneration, activity-dependent events, topographic maps, invertebrate and vertebrate model systems. Prerequisites: graduate standing or consent of instructor.

BGGN 249B-C. Basic Neuroscience (4-4)

These courses are designed for graduate students in the neurosciences and other departments that are part of the interdisciplinary program (i.e., Biology, Cog Sci). These courses have been designed to cover as much basic neuroscience as possible in three quarters of study. They will combine two three-hour meetings each week with a 1.5-hour lecture and a 1.5-hour discussion of papers. These are required courses for all first-year neurosciences graduate students. Prerequisites: graduate standing or consent of instructor. (F,W,S)

BGGN 260. Neurodynamics (4)

Introduction to the nonlinear dynamics of neurons and simple neural systems through nonlinear dynamics, bifurcation theory, and chaotic motions. The dynamics of single cells is considered at different levels of abstraction, e.g., biophysical and “reduced” models for analysis of regularly spiking and bursting cells, their dynamical properties, and their representation in phase space. Laboratory exercises will accompany the lectures. Prerequisites: graduate standing or consent of instructor.

BGGN 262. 3D Electron Microscopy Macromolecules (4)

Biological macromolecules and supramolecular complexes as well as organelles, and small cells are being examined in three dimensions by modern electron cryomicroscopy and image reconstruction techniques. The basic principles of transmission electron microscopy and 3D image reconstruction are discussed. Chem 265/BGGN 262 students will be required to complete an additional oral presentation or paper or exam beyond that expected of students in Chem 165/BIMM 162. (May not be offered every year.)   

BGGN 266. Advanced Laboratory in Biophysical Techniques (6)

Experiments that emphasize biophysical principles through hands-on experience, with an emphasis on the blending of physical measurements with a clearly identified biological problem. Exercises include the use of optical tweezers to measure viscous forces at the level of cellular organelles, the characterization of sensorimotor control in the fly during visually guided flight, and the use of microscopic imaging techniques to characterize cell motility and organelle transport. Includes instruction in LabView. Students are encouraged to attend the Phys 173 undergraduate lectures. Prerequisites: graduate standing or consent of instructor. Phys 120A, BILD 1, and Chem 6CL for undergraduates.

BGGN 271. Advanced Experimental Methods in Biology (4–12)

Advanced laboratory and/or field experience in contemporary biological methodology. Open only to students enrolled in the integrated Bachelor’s/Master’s Degree Program. Prerequisites: consent of instructor and approval of division chair. (Graduate students: letter grades only.) (F,W,S)

BGGN 290. Advances in Cellular and Molecular Mechanisms

Students present and discuss papers on recent discoveries involving basic mechanistic research into biological phenomena. Papers are selected by instructors from visiting seminar speaker’s research from the biological sciences and biochemistry seminar series. Prerequisites: graduate (PhD) standing only; for students in the following major code BI77, or consent of instructor. (S/U grades only.)

BGGN 292. Professional Pathways in Biological Sciences (1)

Students meet experienced science professionals from a wide variety of backgrounds, including academia, science industry, and allied roles. Through discussions with these professionals, students will refine and improve their professional skills, including communication and presentation expertise, and develop a personal career action plan. Prerequisites: graduate (PhD) standing only; for students in the following major code BI77; or consent of instructor. (S/U grades only.)

BGGN 297. Research Conference (1–3)

Group and individual discussion of research activities and of current literature. Prerequisites: graduate standing. (S/U grades only.) (F,W,S)

BGGN 298. Laboratory Projects in Biology (3–12)

An introduction to contemporary laboratory techniques and research interests through independent, original projects under the direction of individual faculty members. Prerequisites: consent of instructor. (Letter grades only) (F,W,S)

BGGN 299. Thesis Research in Biology (1–12)

(F,W,S)

BGGN 500. Apprentice Teaching (4)

This course involves participation in upper-division undergraduate teaching at the level of assuming responsibility for recitation sections or laboratories under the supervision of the responsible faculty member. Some experience in lecturing to upper-division classes will occasionally be provided. (S/U grades only.) (F,W,S)

BGJC 201. Journal Club in Cell Biology (1)

Weekly presentations and discussions pertaining to research results reported in recently published literature. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.) (F,W,S)

BGJC 203. Journal Club in HIV Molecular Biology (1)

Weekly presentations and discussions pertaining to research results reported in recently published literature. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.) (F,W,S)

BGJC 208. Journal Club in Plant Molecular Biology (1)

Weekly presentations and discussions pertaining to research results reported in recently published literature. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.) (F,W,S)

BGJC 213. Journal Club in Computational Neurobiology (1)

Weekly presentations and discussions pertaining to research results reported in recently published literature. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 204. Molecular Biology of the Cell (1)

Research reports and discussions based on recent experimental results in cell biology, oncogenesis, genetics, molecular biology and development. Students are expected to present and discuss their own new data and the recent data of others. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 205. Research Discussion in Plant Membrane Biology (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 206. Research Discussion in Metals in Biology (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 207. Research Discussion in Neuronal Pattern Generation (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 210. Research Discussion in Virology (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 211. Research Discussion in Developmental Cellular Neurobiology (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 212. Research Discussion in Behavior and Development of Simple Nervous Systems (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 213. Research Discussion in Golgi Structure and Function (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 215. Research Discussion in Lymphocyte Biology (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 216. Research Discussion in Molecular and Cell Biology (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 218. Research Discussion in Plant Molecular Genetics (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 219. Research Discussion in Molecular Biophysics (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 221. Research Discussion in Behavioral Ecology (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 222. Research Discussion in Evolutionary Molecular Ecology (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 223. Research Discussion in Ecology (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 225. Research Discussion in Genetic Variation (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 227. Research Discussion in Intracellular Signaling (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 228. Research Discussion in Drosophila Developmental Biology (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 230. Research Discussion in Cell Signaling Pathways (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 231. Research Discussion in Nuclear Transport and Function (1)

Presentations of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGRD 234. Research Discussion in Cell Signaling in Drosophila (3)

Presentation of new research results and discussions of closely related published reports. All students are expected to report on their own research findings each quarter. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGSE 200. Seminar in Biology (1)

Invited speakers from the U.S. and abroad, who are leaders in various aspects of biological research, describe their current research. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.) (F,W,S)

BGSE 202. Seminar in Immunology (1)

Invited speakers from the U.S. and abroad, who are leaders in various aspects of biological research, describe their current research. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.) (F,W,S)

BGSE 203. Seminar in Population Biology (1)

Invited speakers from the U.S. and abroad, who are leaders in various aspects of biological research, describe their current research. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.)

BGSE 204. Seminar in Developmental Genetics (1)

Invited speakers from the U.S. and abroad, who are leaders in various aspects of biological research, describe their current research. Prerequisites: none for graduate students. Undergraduates must be seniors or enrolled in BISP 199. (S/U grades only.) (F,W,S)

BGSE 205. Graduate Research Seminar (1)

Discussions of recent research in various aspects of biological research conducted by third- and fourth-year doctoral students in the Division of Biological Sciences. (S/U grades only.) (F,W,S)